α,ω-dipropionic acid octaethylene glycol
Bis-PEG10-acid
CAS: 1268488-70-5
Molecular Formula: C22H42O13
α,ω-dipropionic acid octaethylene glycol - Names and Identifiers
| Name | Bis-PEG10-acid |
| Synonyms | Bis-PEG25-acid COOH-PEG8-COOH Bis-PEG10-acid HOOC-PEG8-COOH HOOCCH2CH2-PEG24-CH2CH2COOH HOOCCH2CH2O-PEG8-CH2CH2COOH α,ω-dipropionic acid octaethylene glycol |
| CAS | 1268488-70-5 |
α,ω-dipropionic acid octaethylene glycol - Physico-chemical Properties
| Molecular Formula | C22H42O13 |
| Molar Mass | 514.56 |
| Density | 1.174±0.06 g/cm3(Predicted) |
| Boling Point | 630.0±55.0 °C(Predicted) |
| pKa | 3.97±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
α,ω-dipropionic acid octaethylene glycol - Reference Information
| biological activity | Bis- PEG9- acid is a PROTAC linker, belonging to the PEG class. Bis- PEG9- acid can be used to synthesize a series of PROTAC molecules. Bis- PEG9- acid is a degradable (cleavable) ADC linker used in the synthesis of antibody-coupled drugs (ADCs). |
| target | PEGs Cleavable |
| in vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
Last Update：2024-04-09 15:16:39
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